SKELDEV Extreme® Supplement
SKELDEV Extreme® Supplement
Reported in preclinical studies:
- Promoted longitudinal skeletal (height) growth
- Increased growth hormone signaling
- Enhanced IGF-1 activity
- Upregulated IGFBP-3 expression
- Activated JAK2/STAT5 signaling
- Enhanced growth-plate development
- Increased chondrocyte proliferation
- Expanded hypertrophic growth-plate zones
- Increased osteocalcin activity
- Increased BMP-2 expression
- Increased osteoblast proliferation
- Enhanced collagen and ALP expression
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90-Day Guarantee
90-Day Guarantee
We offer a 90-day money-back guarantee.
If for any reason you're not completely satisfied with your purchase, we'll issue a full refund, no questions asked. Simply reach out to our support team for assistance.
The Science Behind It
The Science Behind It
SKELDEV® combines eight research-selected ingredients that have been investigated in preclinical studies for longitudinal skeletal growth, growth-hormone signaling, and growth-plate biology. Individual studies reported effects involving longitudinal bone growth, growth hormone and IGF-1 signaling, IGFBP-3 expression, JAK2/STAT5 activation, BMP-2 expression, chondrocyte proliferation, growth-plate development, and osteogenic activity.
Rather than focusing on a single mechanism, SKELDEV brings together ingredients studied across several interconnected growth pathways. PCE was associated with increased GH, IGF-1, IGFBP-3, and JAK2/STAT5 signaling, while Allium macrostemon, Amomum villosum, Velvet Antler, Eleuthero, and Cibotium barometz were investigated for effects involving longitudinal bone growth, growth-plate development, IGF-1, BMP-2, and chondrocyte activity. Fenugreek Seed Extract standardized for dioscin adds an additional upstream component, with dioscin studied for pronounced growth-hormone release in cultured rat pituitary cells.
Shipping & Returns
Shipping & Returns
We offer tracked shipping on all orders.
All orders are processed by our careful fulfilment team within 24 business hours.
We are currently experiencing high volume of orders so delivery times, depending on your location, range from 5-13 business days.
We've made returning products super easy. Simply contact us info@skeldev.com and we'll handle everything
Is It Safe / Side Effects?
Is It Safe / Side Effects?
Yes, SKELDEV® uses botanical and nutritional ingredients with prior research and histories of safe use.
Side effects primarily result from the accelerated growth itself and may include “growing pains,” particularly in the knees, shins, and thighs, which are often more noticeable at night.
Ingredients
Ingredients
Each daily serving of 3 capsules provides six concentrated 10:1 extracts, with 200 mg of each ingredient per serving.
Eleuthero Root Extract (10:1) — 200 mg
Equivalent to approximately 2 g of starting root material.
Yeast Hydrolysate (10:1) — 200 mg
Equivalent to approximately 2 g of starting material.
Amomum villosum Fruit Extract (10:1) — 200 mg
Equivalent to approximately 2 g of starting fruit material.
Phyllostachyos Caulis in Taeniam Extract (10:1) — 200 mg
Equivalent to approximately 2 g of starting botanical material.
Velvet Antler Extract (10:1) — 200 mg
Equivalent to approximately 2 g of starting material.
Allium macrostemon Bulb Extract (10:1) — 200 mg
Equivalent to approximately 2 g of starting bulb material.
A 10:1 extract means roughly 10 parts of starting material are used to produce 1 part of extract, so 200 mg of a true 10:1 extract corresponds to approximately 2 g of starting material.
Serving Size: 3 Capsules
Servings Per Container: 30
Total Capsules: 90
Total Extracts Per Serving: 1,200 mg
Nominal Starting-Material Equivalent: approximately 12 g per serving
Frequently Asked Questions
Frequently Asked Questions
What is SKELDEV?
SKELDEV is an eight-ingredient multi-botanical formula built around ingredients studied in preclinical research for longitudinal skeletal growth (height), growth-plate activity, GH–IGF-1 signaling, JAK2/STAT5 activation, and related pathways.
How do I take it?
Take 3 capsules daily. Each bottle contains 90 capsules, providing a 30-day supply.
How much of each ingredient is included?
Each daily serving provides 200 mg of each 10:1 extract, for 1,200 mg of total extracts.
What does 10:1 extract mean?
A 10:1 extract means approximately 10 parts of starting material are used to produce 1 part of extract. Therefore, 200 mg of a true 10:1 extract corresponds nominally to about 2 g of starting material.
What ingredients are included?
Eleuthero Root Extract, Yeast Hydrolysate, Amomum villosum Fruit Extract, Phyllostachyos Caulis in Taeniam Extract, Velvet Antler Extract, Allium macrostemon Bulb Extract, Fenugreek Seed Extract standardized for Dioscin, and Cibotium barometz Rhizome Extract.
What research is SKELDEV based on?
The formula was selected around ingredients individually investigated in preclinical studies for effects involving longitudinal bone growth, growth hormone, IGF-1, IGFBP-3, STAT5, BMP-2, chondrocyte proliferation, growth-plate development, and osteogenic activity.
3.24× Height Growth. 24.13× Growth Hormone Increase. 5.20× IGF-1 mRNA Expression
Every Ingredient Carefully Chosen
Every ingredient in our formula is there for a reason, and backed by peer-reviewed research in mice & rats, not marketing fluff. We don’t hide behind “proprietary blends” or vague labels. You get a clear, transparent list of clinically supported ingredients, each included at a meaningful dose and a 10:1 ratio,
The evidence behind
every ingredient
Explore why each ingredient was selected, how it fits the formula, and the research used to inform that choice.
Formula ingredient
Eleuthero
A standout preclinical growth-plate ingredient with unusually strong longitudinal-growth data
Why it’s included
Eleuthero is included as a high-interest preclinical growth-plate ingredient with some of the most striking longitudinal-growth data in the research set. It contributes to the formula’s focus on skeletal-growth and local growth-plate biology.
How it works
Preclinical evidence suggests Eleuthero may act at the level of the growth plate, increasing development of the proliferative and hypertrophic zones while also enhancing local IGF-1 and BMP-2 signaling. This points to a mechanism centered more on local skeletal signaling than simple systemic hormone elevation alone.
In the formula
Eleutherococcus senticosus Root Extract (10:1)
200 mg per serving
Formula ingredient
Yeast Hydrolysate
One of the strongest oral preclinical growth-velocity ingredients reviewed
Why it’s included
YH is included for its strong preclinical profile in growth velocity and GH-associated signaling. It serves as a core ingredient for the formula’s growth-axis support concept.
How it works
Preclinical studies suggest YH may help stimulate growth hormone release and support growth-plate activity, contributing to faster longitudinal bone-growth velocity in juvenile animal models. The observed increase in proximal epiphyseal growth supports a direct relationship with active skeletal growth processes.
In the formula
Yeast Hydrolysate (10:1)
200 mg per serving
Formula ingredient
Amomum villosum
A single-botanical extract that outperformed rhGH in one rat growth model
Why it’s included
Amomum villosum is included as a single-botanical growth-plate support ingredient. It helps anchor the formula in ingredients that showed not just hormonal movement, but also direct evidence of growth-plate activation and chondrocyte proliferation.
How it works
Preclinical work suggests Amomum villosum may support local growth-plate signaling, including IGF-1 and BMP-2, while increasing proliferative activity in chondrocytes. That makes it one of the more compelling plant extracts for growth-plate-directed support.
In the formula
Amomum villosum Fruit Extract (10:1)
200 mg per serving
Formula ingredient
Velvet Antler
A classic skeletal-development ingredient with added bone-formation support
Why it’s included
Velvet antler is included to support the formula’s bone-formation and skeletal-development profile. It adds a distinct preclinical signal for both longitudinal growth and osteoblast-driven bone activity.
How it works
Preclinical data suggest velvet antler may support growth-plate development and bone-forming cell activity, including increases in BMP-2 and osteoblast-related markers. This gives it a dual role in the formula: skeletal growth support plus bone-formation signaling.
In the formula
Velvet Antler Extract (10:1)
200 mg per serving
Formula ingredient
Allium macrostemon
A growth-plate botanical that outperformed rhGH in one preclinical model
Why it’s included
Allium macrostemon is included as a growth-plate signaling ingredient that adds another independent preclinical line of support for skeletal-growth pathways, especially through IGF-1 and BMP-2-related effects.
How it works
Preclinical findings suggest Allium macrostemon may support local growth-plate biology, including IGF-1 and BMP-2 expression, which are both closely associated with chondrocyte development and endochondral growth processes.
In the formula
Allium macrostemon Bulb Extract (10:1)
200 mg per serving
Formula ingredient
PCE
A lead preclinical ingredient for GH–IGF-1 and tibial-growth signaling
Why it’s included
PCE is included as one of the formula’s lead preclinical ingredients for GH–IGF-1 axis support and longitudinal bone-growth signaling. Among the ingredients reviewed, it showed one of the strongest combined profiles for actual bone-length gain plus mechanistic biomarker activation.
How it works
Preclinical findings suggest PCE may help activate the growth hormone receptor pathway, increasing downstream JAK2/STAT5 signaling, which in turn may upregulate IGF-1 and IGFBP-3. That pathway is closely tied to growth-plate activity, skeletal development, and bone-formation signaling.
In the formula
Phyllostachyos Caulis in Taeniam Extract (10:1)
200 mg per serving
Formula ingredient
Dioscin
A high-interest preclinical ingredient for potent growth-hormone release signaling.
Why it’s included
Dioscin is included for its unusually strong preclinical GH-release activity. In cultured rat pituitary cells, it produced one of the most pronounced growth-hormone secretagogue responses identified among the ingredients reviewed.
How it works
Preclinical findings suggest dioscin may act directly at the level of pituitary somatotrophs, stimulating growth-hormone release and potentially supporting upstream GH–IGF-1 axis signaling. The precise receptor-level mechanism remains preclinical.
In the formula
Fenugreek Seed Extract (10:1)
standardized for Dioscin
200 mg per serving
Formula ingredient
Cibotium barometz
A standout preclinical ingredient for longitudinal bone growth and growth-plate development.
Why it’s included
Cibotium barometz is included for its unusually strong longitudinal-growth data. In adolescent male rats, it produced one of the largest direct skeletal-growth responses identified among the botanical ingredients reviewed.
How it works
Preclinical evidence suggests Cibotium barometz may support growth-plate development, including expansion of the proliferative and hypertrophic zones, alongside increased local BMP-2 expression. IGF-1 expression was not significantly increased in that study.
In the formula
Cibotium barometz Rhizome Extract (10:1)
200 mg per serving
Research summaries are provided for educational context. Preclinical or animal-model findings should not be interpreted as demonstrated outcomes in humans. Individual ingredients may perform differently when used in a combined formula.
3.24× Height Growth. 24.13× Growth Hormone Increase. 5.20× IGF-1 mRNA Expression
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Help shape the next chapter of SKELDEV® research
We are preparing for potential U.S.-based clinical research in 2027. The planned study will evaluate defined outcomes under a formal protocol, subject to ethics, regulatory, and operational review.
This announcement is for planning information only and is not active clinical-trial recruitment. Timing, eligibility, locations, protocol, and study launch may change.